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What is pethidine?

2025-12-07 13:01:22 healthy

What is pethidine?

Pethidine, also known as pethidine, is a synthetic opioid analgesic mainly used to relieve moderate to severe pain. In recent years, pethidine has become one of the hot topics of public concern due to its pharmacological effects and potential abuse risks. The following is a detailed introduction to pethidine, including its pharmacological effects, uses, side effects and recent hot topics.

1. Basic information about pethidine

What is pethidine?

Projectcontent
common namePethidine
AliasPethidine, Demerol
drug classopioid analgesics
IndicationsModerate to severe pain, preoperative analgesia, labor analgesia
Dosing methodOrally, intramuscularly, intravenously

2. Pharmacological effects of pethidine

Pethidine inhibits the transmission of pain signals by acting on opioid receptors in the central nervous system, thereby achieving analgesic effects. Its mechanism of action is similar to that of morphine, but its duration of action is shorter and its addiction is relatively low. However, long-term use may still lead to dependence and tolerance.

Pharmacological propertiesDescription
analgesic effectAbout 1/10 of morphine
Action time2-4 hours
Metabolic pathwaysLiver metabolism, renal excretion

3. Uses of pethidine

Pethidine has a variety of clinical uses, including:

  • Postoperative analgesia:For pain relief after surgery.
  • Labor analgesia:Reduces maternal pain during childbirth.
  • Cancer pain:For pain management in patients with advanced cancer.

However, because norpethidine, the metabolite of pethidine, is neurotoxic and long-term use may cause adverse reactions such as convulsions, its clinical application has gradually decreased in recent years.

4. Side effects of pethidine

Common side effects of pethidine include:

Side effect typeSpecific performance
nervous systemDizziness, drowsiness, respiratory depression
digestive systemNausea, vomiting, constipation
cardiovascular systemDrop in blood pressure, bradycardia
Othersdependence, tolerance

5. Recent hot topics

In the past 10 days, pethidine has become a hot topic due to controversy over its abuse risks and medical uses. The following are some hot topics:

  • Increased cases of abuse:Cases of illegal circulation of pethidine have been reported in many places, arousing public attention on drug supervision.
  • Alternative Medicine Research:As the side effects of pethidine have been widely recognized, more research has focused on developing safer analgesics.
  • Medical disputes:Some doctors believe pethidine remains irreplaceable in certain circumstances, while other experts have called for restrictions on its use.

6. Summary

As a powerful analgesic, pethidine plays an important role in the medical field, but its potential abuse risks and side effects cannot be ignored. The public should understand its proper use and avoid misuse. At the same time, the medical community is also actively exploring safer alternatives to balance the need for analgesia and medication safety.

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